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55/100
Standard
Six-dimension breakdown
Evidence
52
Formulation
55
Manufacturing
55
Safety
62
Transparency
55
Sustainability
50
Why this scored 55/100
NusaPure Calcium D-Glucarate at 500 mg per capsule delivers a dose within the studied range for beta-glucuronidase inhibition and estrogen/toxin conjugate clearance. Calcium D-glucarate is a natural compound found in fruits and vegetables that yields D-glucaric acid in vivo, which inhibits intestinal beta-glucuronidase and reduces enterohepatic recycling of glucuronidated compounds (estrogens, xenobiotics). Human pharmacokinetic data (Walaszek 1996) supports 1500-4500 mg/day as effective for beta-glucuronidase inhibition; some estrogen-metabolism protocols use 1-2 g/day (Heerdt 1995). NusaPure's 500 mg per capsule is within the low end of studied doses per capsule and users could reasonably scale to 3 capsules/day. Single-ingredient, honest dose disclosure, defensible mechanism. Held out of Verified by absence of third-party purity testing and no marker standardization discussion.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
0–19: No credible evidence base or unverifiable claims.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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VSF score
55 / 100
Tier
Standard
Category
Supplements
Subcategory
hormonal endocrine
Last scored
Third-party certifications
None on record at time of scoring
Vendor
NusaPure
Tags
NusaPure, Shopify Collective
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
