Optimum Nutrition
THE BIOHACKING STANDARD
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Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
This is the best-scoring SKU in the batch and one of the few that discloses the actual silymarin content — '175 mg Silymarin' — clearing the 150 mg therapeutic threshold established in NAFLD trials (Zhong 2019 meta-analysis, ~-9 U/L ALT reduction at 140-450 mg daily). Marketing is honest — 'for Liver Support', no detox/cleanse/flush claims. Nature's Bounty is a legacy US retail brand with NSF cGMP and Nestlé Health Science ownership. The transparency of naming silymarin mg on the label (rather than the misleading 'milk thistle 1000 mg' framing many competitors use) is a real formulation positive. Would move to Verified 75+ with per-lot COA and switch to silybin-phytosome format for 4-10x bioavailability improvement.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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