Nature Made Folic Acid 400 Mcg Tablets, 250 Tablets

Six-dimension breakdown

Why this scored 68/100

Nature Made Folic Acid 400 mcg is a single-ingredient tablet at the exact RDA-adjacent daily dose for adults, with 250-tablet supply for cost-efficient long-term use. The specific ingredient has one of the highest-evidence supplement contexts in the entire category: folic acid supplementation in women of childbearing age reduces the risk of neural tube defects (spina bifida, anencephaly) by 50-70% (MRC Vitamin Study 1991, Czeizel 1992), and CDC and USPHS guidance since 1992 has been that all women of childbearing potential take 400 mcg folic acid daily. This is one of the strongest public-health-supported supplement recommendations in medicine. Nature Made brand offers USP Verified certification on many SKUs (should be verified per-bottle). No gluten, no color additives, no artificial flavors is a clean formulation. Approaches Verified tier for the pregnancy-prevention indication. Held from Verified by absence of visible USP mark on this specific SKU listing (may be present on physical label).

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

68 / 100

Tier

Standard

Category

Supplements

Subcategory

womens health

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

Pasteur Pharmacy

Product type

Vitamins & Supplements

Tags

Pasteur Pharmacy, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.