NAD+

NAD+ is a product from 1776 Sports Nutrition LLC, categorized under Longevity & cellular health in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.

45/100 overall — Rejected tier (0–49 band). Per-dimension breakdown: Safety 60, Formulation 45, Manufacturing 45, Sustainability 45, Evidence 42, Transparency 38. Scored as of 2026-08-24.

'NAD+' branded product from small vendor 1776 Sports Nutrition. Held below Standard by two structural issues: (1) DIRECT ORAL NAD+ has a mechanism problem — NAD+ is a large charged molecule that doesn't cross the gut wall intact; oral NAD+ is broken down to nicotinamide + ADP-ribose in the GI tract, then absorbed and re-synthesized intracellularly. Products labeled 'NAD+' without disclosing whether they're actually NAD+, NR, NMN, or plain niacinamide are marketing ambiguity that hides the actual active. Effective NAD+ precursor supplementation uses NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide) — both of which have their own published bioavailability data. (2) 1776 Sports Nutrition is a small brand without established quality track record. (3) Per-cap dose not disclosed at product name. (4) No third-party COA. Would move to Standard 55+ with clarity on actual active molecule + dose + established sourcing.

Strongest: Safety at 60/100 (adverse-event profile, interaction risk, and dose ceiling) and Formulation at 45/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Evidence at 42/100 (quality of published RCT support for the active ingredients at the label dose) and Transparency at 38/100 (dose disclosure vs proprietary blends, and honesty of marketing claims). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.

No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.

Would move to Standard 55+ with clarity on actual active molecule + dose + established sourcing.

The top-ranked longevity & cellular health product in the Vyvata catalog is currently Tru Niagen - Niagen 300 mg Nikotinamid Ribosid Supplement for Anti-Aging & Cellular Energy Support - 30 Capsules at 78/100. See the full ranked list of 131 scored products in this subcategory at https://vyvata.com/pages/best-longevity-and-cellular-health-supplements-ranked.

The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.

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