Optimum Nutrition
THE BIOHACKING STANDARD
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NYC Herbs sells a proprietary 'Liver Health Blend' with no disclosed silymarin standardization, no per-herb mg breakdown, and marketing language leaning heavily on generalized 'liver support' framing rather than the specific hepatoprotective indications (NAFLD ALT/AST reduction, alcoholic-liver support) where silymarin has modest evidence (Cochrane 2007 Rambaldi; Zhong 2019 NAFLD meta-analysis, WMD ~-9 U/L ALT). Proprietary-blend format prevents users from confirming a therapeutic 150-300 mg silymarin dose. Small herbalist brand with no third-party COA visible. Not autofailed on the title alone, but formulation/transparency floor keeps it in Rejected. Would move to Standard 60+ only with per-ingredient mg disclosure and standardization to 80% silymarin at a clinically studied dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
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