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60/100
Standard
Six-dimension breakdown
Evidence
52
Formulation
68
Manufacturing
62
Safety
68
Transparency
58
Sustainability
48
Why this scored 60/100
Neurogan Health Liposomal Spermidine Capsules deliver 50 mg of spermidine per capsule using a synthetic wheat-free source (allows precise dosing, gluten-free) in a phospholipid liposomal delivery system. 50 mg is substantially above the 1-6 mg doses used in the Wirth 2018 / Schwarz 2018 cognitive RCTs and above the ~7 mg dietary intake associated with the Kiechl 2018 mortality-benefit observational data. Liposomal delivery is a defensible bioavailability strategy for polyamines, which are otherwise subject to gut-bacterial metabolism and intestinal enzyme degradation, though product-specific PK data are not published. Standard tier — legitimate delivery format, honest brand, but the dose is well above the studied range without corresponding human outcome data at that dose, and the transparency gap on per-lot COA holds it below Verified.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
0–19: No credible evidence base or unverifiable claims.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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VSF score
60 / 100
Tier
Standard
Category
Supplements
Subcategory
longevity cellular
Last scored
Third-party certifications
None on record at time of scoring
Vendor
Neurogan Health
Product type
Vitamins & Supplements
Tags
Neurogan Health, Shopify Collective
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
