Deplin FC L-methylfolate Ca 15mg Medical Food – 90 Capsules

Deplin FC L-methylfolate Ca 15mg Medical Food – 90 Capsules, categorized under Stress, mood & mental wellness in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.

76/100 overall — Verified tier (70–84 band). Per-dimension breakdown: Evidence 82, Formulation 82, Manufacturing 78, Transparency 78, Safety 70, Sustainability 55. Scored as of 2026-08-24.

Deplin is the original prescription-tier medical food L-methylfolate (5-MTHF calcium salt) at 15 mg, positioned as an adjunct for major depressive disorder in patients with MTHFR polymorphisms or SSRI partial response. The evidence base is unusually strong for this class — Papakostas 2012 (two 60-day RCTs, 15 mg L-methylfolate adjunct to SSRI beat placebo in SSRI non-responders) is the anchor trial, and 5-MTHF is the bioavailable methylated form that bypasses MTHFR pathway bottlenecks. Formulation is best-in-class (Metafolin/L-methylfolate calcium, not folic acid), and dose matches the RCT. Held below Elite because it's a medical food dispensed under practitioner supervision (drug-interaction risk with methotrexate, some SSRIs, and monitoring needs for bipolar activation), and sustainability data isn't published. Would move to Elite in a consumer context with clearer per-lot analytical certificates and expanded safety-monitoring guidance.

Strongest: Evidence at 82/100 (quality of published RCT support for the active ingredients at the label dose) and Formulation at 82/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Safety at 70/100 (adverse-event profile, interaction risk, and dose ceiling) and Sustainability at 55/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.

No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.

Would move to Elite in a consumer context with clearer per-lot analytical certificates and expanded safety-monitoring guidance.

The top-ranked stress, mood & mental wellness product in the Vyvata catalog is currently Momentous Sleep at 77/100. See the full ranked list of 247 scored products in this subcategory at https://vyvata.com/pages/best-stress-mood-and-mental-wellness-supplements-ranked.

The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.

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