Centrum Age Defy Men's High Potency Multivitamin 60 Caplets

Centrum Age Defy Men's High Potency Multivitamin 60 Caplets is a product from Centrum, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.

62/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Evidence 68, Manufacturing 68, Safety 65, Transparency 60, Formulation 58, Sustainability 55. Scored as of 2026-08-24.

Centrum is Haleon-owned (spun off from GSK 2022) — one of the most-studied multivitamins in the world, with Physicians' Health Study II (Sesso 2012 JAMA) using Centrum Silver over 11 years and showing modest reductions in total cancer incidence and cataracts in older men. Age Defy Men's is the higher-potency version with added lutein/zeaxanthin and lycopene. Held at mid-Standard because the formulation uses folic acid (not methylfolate), cyanocobalamin (not methylcobalamin), and mineral-oxide forms (magnesium oxide, calcium carbonate) with lower bioavailability than chelated alternatives, and it's a compressed caplet rather than veggie cap. Would move to Verified with methylated B-vitamins, chelated minerals, and per-lot COA.

Strongest: Evidence at 68/100 (quality of published RCT support for the active ingredients at the label dose) and Manufacturing at 68/100 (third-party testing, GMP compliance, and facility audit status). Weakest: Formulation at 58/100 (dose adequacy, bioavailability form, and ingredient redundancy) and Sustainability at 55/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.

No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.

Would move to Verified with methylated B-vitamins, chelated minerals, and per-lot COA.

The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 635 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.

The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.

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