NAD+

NAD+ Complex with Quercetin & Resveratrol

A dietary supplement providing 500 mg of NAD+ (nicotinamide adenine dinucleotide) combined with quercetin and resveratrol. This formula is designed to support cellular energy metabolism, mitochondrial function, and overall cellular health through three complementary compounds studied for their roles in aging, metabolism, and cellular resilience.

What's In It:

• NAD+ (Nicotinamide Adenine Dinucleotide) - 500 mg: A critical coenzyme present in every cell that functions as an electron carrier in cellular respiration. NAD+ exists in two forms: NAD+ (oxidized) and NADH (reduced), and this interconversion is fundamental to energy metabolism.

NAD+'s Cellular Roles:

• Essential cofactor for glycolysis, the citric acid cycle, and the electron transport chain—the processes that convert nutrients into ATP (cellular energy)
• Substrate for sirtuins (SIRT1-7)—proteins that regulate DNA repair, gene expression, inflammation, and metabolic homeostasis
• Required by PARPs (poly ADP-ribose polymerases)—enzymes involved in DNA repair and genome stability
• Substrate for CD38 and other NAD+-consuming enzymes involved in cellular signaling

The NAD+ Decline Issue: Research demonstrates that NAD+ levels decline with age—by approximately 50% between ages 40-60 in various tissues. This decline is attributed to:

• Increased consumption by CD38 (which increases with age)
• Decreased synthesis from precursors
• Increased NAD+ degradation
• Reduced mitochondrial function

Declining NAD+ levels correlate with reduced sirtuin activity, impaired mitochondrial function, decreased cellular repair capacity, and various age-related metabolic changes.

Oral NAD+ Supplementation: A critical consideration: NAD+ is a large, charged molecule (molecular weight 663 g/mol) that has poor bioavailability when taken orally. It's generally broken down in the digestive tract into component parts (nicotinamide, ribose, adenine). Most longevity researchers focus on NAD+ precursors like NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) rather than direct NAD+ supplementation, as precursors have demonstrated better absorption and ability to raise cellular NAD+ levels.

However, some research suggests that enteric coating or specific formulation methods may protect NAD+ through digestion, though evidence is still emerging. This product provides direct NAD+ rather than precursors.

• Quercetin Dihydrate Extract (250 mg): A flavonoid polyphenol found in onions, apples, berries, and other plants. Quercetin has been studied for:

• Antioxidant properties (directly scavenges free radicals)
• Senolytic potential (may help clear senescent "zombie" cells that accumulate with age)
• Support for healthy inflammatory response pathways
• Potential to inhibit CD38 (the enzyme that degrades NAD+), theoretically helping preserve NAD+ levels
• Zinc ionophore properties (facilitates cellular zinc uptake)

Quercetin has relatively low bioavailability (approximately 2-17% absorption) but its metabolites may contribute to biological effects.

• Japanese Knotweed Extract (150 mg, standardized to 98% Resveratrol): Provides approximately 147 mg of trans-resveratrol, a polyphenolic stilbene compound also found in grape skins and red wine.

Resveratrol's Studied Effects:

• Sirtuin activator—particularly SIRT1, which regulates mitochondrial biogenesis, fat metabolism, and cellular stress resistance
• Activates AMPK (AMP-activated protein kinase), a key metabolic sensor that promotes fat oxidation and glucose uptake
• Antioxidant and anti-inflammatory properties
• Studied for cardiovascular support through effects on endothelial function and lipid metabolism
• Neuroprotective properties examined in animal models

Bioavailability Challenge: Resveratrol has poor oral bioavailability (approximately 1% reaches systemic circulation unchanged) due to rapid metabolism in the intestines and liver. However, metabolites may retain biological activity, and some research suggests benefits despite low bioavailability.

What It Does:

This supplement aims to support cellular energy production and metabolic health through three mechanisms:

1. Direct NAD+ provision (though absorption challenges apply)
2. Potential NAD+ preservation via quercetin's CD38 inhibition
3. Sirtuin activation through resveratrol, which may complement NAD+'s role as a sirtuin substrate

The combination theoretically addresses cellular energy metabolism, mitochondrial function, DNA repair processes, and cellular stress resistance—all relevant to healthy aging and metabolic function.

Realistic Expectations:

Effects are subtle and cumulative rather than immediately perceptible. Those interested in NAD+ support for longevity or metabolic optimization may notice improvements in energy levels, recovery, or mental clarity over 4-8 weeks of consistent use, though responses vary significantly between individuals.

Important Consideration: The longevity and anti-aging research community generally favors NAD+ precursors (NMN, NR) over direct NAD+ due to bioavailability concerns. If desired effects are not achieved with this formula, NAD+ precursor supplements may be worth exploring.

Who Might Use This:

Adults interested in longevity optimization, cellular health support, metabolic function, individuals experiencing age-related energy decline, biohackers, or those seeking to support healthy aging processes through nutritional supplementation.

Sourcing & Production:

Manufactured in the USA.

Product Specifications:

• Servings per Container: 30 (60 capsules)
• Serving Size: 2 capsules
• Net Weight: 1.8 oz (0.11 lb / 50g)
• Total Weight: 2.4 oz (0.15 lb / 68g)
• Country of Origin: USA

Usage Instructions: Adults: Take two (2) capsules daily with 6 oz (177 ml) of water, preferably with food to enhance absorption of quercetin and resveratrol (both fat-soluble compounds benefit from dietary fat). For optimal results, take consistently at the same time each day, or as directed by your healthcare professional.

Important Safety Information:

Do not exceed recommended dose. Pregnant or nursing women, children under 18, and individuals with known medical conditions should consult a physician before use. Resveratrol may have mild anticoagulant effects—consult your healthcare provider if taking blood-thinning medications.

KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.